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The products generated in this reaction are peroxynitrite (ONOO ) which results from the formation of hydroxyl radical (OH), which is greatly reactive and results in the alteration of cellular functioning and cause dysfunction of endothelial cells, and 3) Massive generation of O 2 may result in proliferation and apoptotic death of epithelial cells (Pacher et al., 2007

In JC virus-infected glioblastoma cells, it is possible to find the same MDR feature